Wei-Ting Lu

Using existing population genomic and clinical data, our lab aims to functionally characterise the events that contribute to whole genome doubling and chromosomal instability. We are interested in FAT protocadherins, a class of proteins which are often mutated in lung, breast, skin and oesophageal cancers. By understanding the role played by the FAT proteins, we aim to find novel treatment strategies.

TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling. Lu W-T. et al, (2025), Nat Cell Biol, 27, 154 - 168 FAT1 alterations contribute to chromosomal instability in cancer cells. (2025), Nat Cell Biol, 27, 12 - 13 Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome. Vendramin R. et al, (2026), Immunity Subclonal immune evasion in non-small cell lung cancer. Dijkstra KK. et al, (2025), Cancer Cell, 43, 1833 - 1849.e10 DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution. Gimeno-Valiente F. et al, (2025), Nat Genet, 57, 2226 - 2237 ImmuneLENS characterizes systemic immune dysregulation in aging and cancer. Bentham R. et al, (2025), Nat Genet, 57, 694 -