Timothy Cernak

Home » Directory » Cernak, Timothy Medicinal Chemistry Timothy Cernak Associate Professor of Medicinal Chemistry, College of Pharmacy, and Associate Professor of Chemistry, College of Literature, Science, and the Arts Accepting Students 734/647-6793 [email protected] College of Pharmacy 930 N University Ann Arbor, MI 48109-1055 3815 Chem Cernak Lab Michigan Experts Website Role Overview and Bio The functional and biological properties of a small molecule are encoded within its structure so synthetic strategies that access diverse structures are paramount to the invention of novel functional molecules such as biological probes, materials or pharmaceuticals. The Cernak Lab studies the interface of chemical synthesis and computer science to understand the relationship of structure, properties and reactions. We aim to use algorithms, robotics and big data to invent new chemical reactions, synthetic routes to natural products, and small molecule probes to answer questions in basic biology. Researchers in the group learn high-throughput chemical and biochemical experimentation, basic coding, and modern synthetic techniques. By studying the relationship of chemical synthesis to functional properties, we pursue the opportunity to positively impact human health. Awards 2026 TEDx Global Idea Search, TED 2025 Hypothesis Fund, Hypothesis Fund 2025 Hypothesis Fund, Hypothesis Fund 2024 Kavli Fellowship, National Academy of Sciences 2023 Sloan Research Fellow, The Sloan Foundation 2022 Schmidt Innovation Fellow, Schmidt Futures 2022 NSF CAREER, National Science Foundation Selected Publications Nathan J. Gesmundo, Bérengère Sauvagnat, Patrick Curran, Matthew P. Richards, Christine L. Andrews, Peter J. Dandliker, Tim Cernak* . “Nanoscale Synthesis and Affinity Ranking”, Nature , 2018 , 557, 228-232 . Tim Cernak* , et al . “Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors”, The Journal of Medicinal Chemistry , 2017 , 60 (9), 3594-3605 . Featured Article. Alexander Buitrago Santanilla, Erik L. Regalado, Tony Pereira, Kevin Bateman, Louis-Charles Campeau, Simon Berritt, Yong Liu, Michael Shevlin, Zhi-Cai Shi, Jonathan Schneeweis, Christopher J. Welch, Roy Helmy, Petr Vachal, Ian Davies, Tim Cernak* and Spencer Dreher*. “Nanomolar-Scale High-Throughput Chemistry for the Synthesis of Complex Molecules”, Science , 2015 , 347 (6217), 49-53. Heike Schönherr and Tim Cernak* .  “Profound Methyl Effects in Drug Discovery and a Call for New C-H Methylation Reactions”, Angewandte Chemie International Edition in English , 2013 , 52 (47), 12256-12267. SEARCH Department Chemical Engineering Clinical Pharmacy College of Pharmacy Community Health and Engagement Dedicated Programs and Assessments Development and Alumni Engagement Experiential Education Facilities and Safety Financial and Human Resources Information Technology Services Marketing and Communications Medicinal Chemistry NMR Core Office of the Dean Pharmaceutical Sciences Pharmacokinetics and Mass Spectrometry Core Research Administration Student Services, Admissions and Academic Affairs Vahlteich Medicinal Chemistry Core Role Faculty Staff PhD Students Has Lab Yes No Items per page 10 25 50 100 All Search Reset

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