Simone Chevalier

Areas of expertise: To establish the clinical and functional significance of protein kinases implicated in the androgen-independent progression of human prostate cancer. Development of new therapeutic modalities for prostate cancer in animal models. Current research: My research focuses on prostatic diseases, benign prostatic hyperplasia (BPH) and prostate cancers (PCa) that spontaneously arise in men 50 years or older. Our mechanistic studies involve the use of diverse in vitro and in vivo approaches to characterise key molecules of signaling pathways mediated by androgens and growth-promoting factors in heterogeneous cell populations of the human and dog prostate cells, tumours and metastases. We also focus on circulatory molecules as potential biomarkers of PCa witnessing tumor cells as they evolve with progression. To translate our findings to patients, we implemented a PCa biobank and adopted a large animal (canine) model of PCa. Clinical Interests: Liquid biopsies to identify new markers of lethal prostate cancer; Prostate cancer progression.; Intra-tumoral heterogeneity and diversity of prostate cell subtypes Areas of interest: Prostatic diseases