Seth Cheetham

A/Prof. Seth Cheetham is an ARC Future Fellow and Group Leader at the Australian Institute for Bioengineering and Nanotechnology. He is also the Director of the National Biologics Facility, Australia's leading bio-manufacturing hub. He completed his PhD at the University of Cambridge, supported by the Herchel Smith Research Studentship. Seth is a molecular biologist and geneticist with a focus on biotherapeutics, mRNA and bio-manufacturing. He has authored >30 publications, in some of the most influential molecular biology journals including Science, Molecular Cell, Nature Reviews Genetics, Nature Protocols, Genome Biology and Nature Structural and Molecular Biology. His work has attracted > $85M in competitive funding including eleven years of continuous NHMRC and ARC Fellowship support. In 2021 Seth was awarded the Genetics Society of Australasia Alan Wilton Early Career Award. Biochemistry and cell biology; Bioinformatics and computational biology; Biological Sciences; Epigenetics (incl. genome methylation and epigenomics); Gene expression (incl. microarray and other genome-wide approaches); Genetics; Genomics

2025 - The design, manufacture and LNP formulation of mRNA for research use 2025 - Targeted mRNA delivery with bispecific antibodies that tether LNPs to cell-surface markers 2025 - Enhancement of anti-sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2-targeted CAR 2026 - Systemically delivered mRNA-LNPs transfect primary and secondary liver tumors 2026 - Chemically and enzymatically synthesised messenger RNA as a therapeutic agent 2026 - Development of a high-affinity anti-ROR1 variable region for broad anti-cancer immunotherapy 2025 - Mind the cap: Detecting degradation impurities in synthetic mRNAs 2025 - Evaluating mRNA delivery using nuclear medicine 2025 - Targeted DamID detects cell-type-specific histone modifications in intact tissues or organisms 2024 - A s