Rebecca Page

How we sense and react to our environment is communicated in the cell by vast networks of highly dynamic, interacting proteins. These interactions are regulated in both space and time, and it is this tight regulation that allows signals from outside of the cell to be rapidly and precisely transmitted to the nucleus leading to the appropriate, and healthy, cellular response. We integrate structural biology, cell biology, genetics and biochemistry in order to understand how these signals in both prokaryotes and eukaryotes are communicated in the cell at atomic resolution.

[2026] The clinical missense variant E282K in PPP3CA/calcineurin shifts substrate dephosphorylation by altering active site recruitment. [2025] Peptidoglycan recruitment by a penicillin binding protein. [2025] Mechanistic and evolutionary insights into a family of aminoacyl-tRNA deacylases that protects against canavanine toxicity. [2025] PNUTS:PP1 recruitment to Tox4 regulates chromosomal dispersal in Drosophila germline development. [2025] Cryo-EM structures of PP2A:B55 with p107 and Eya3 define substrate recruitment. [2025] The phosphate of life. [2025] Using hybrid methods to define the molecular basis of the phosphoprotein phosphatase (PPP) family regulation and substrate specificity [2025] Combining cryo-electron microscopy (cryo-EM) with orthogonal solution state methods to define t