Rashmi Bansal, PhD

Developmental, cellular and molecular biology of Oligodendrocytes, the cells that synthesize myelin membrane in the central nervous system; growth factor regulation of development and function and its relationship to neurodegenerative disease, including Multiple Sclerosis.Current research is focused on investigation of basic mechanisms of cell biology in a developmental context. (oligodendrocyte developmental lineage is the model system)--Molecular mechanisms of regulation of differentiation by growth factor receptors, including the application of transgenic mouse models, cell culture and transfection systems.<br />--Membrane biogenesis and function, including the role of glycosphingolipid-cholesterol microdomains (rafts) and signal transduction.<br />--The relationship of these to Multiple Sclerosis

[2021] Mek/ERK1/2-MAPK and PI3K/Akt/mTOR signaling plays both independent and cooperative roles in Schwann cell differentiation, myelination and dysmyelination. [2020] Developmental stage-specific role of Frs adapters as mediators of FGF receptor signaling in the oligodendrocyte lineage cells. [2019] Corrigendum: Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy. [2019] Independent and cooperative roles of the Mek/ERK1/2-MAPK and PI3K/Akt/mTOR pathways during developmental myelination and in adulthood. [2019] Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy. [2018] Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital