Pik Kwan Peggy LO, 羅璧君

Chemical Biology DNA Chemistry Synthetic Chemistry Biomimetics Biomolecular Sensing Bioimaging Our research group focuses on design and assembly of bio-inspired DNA-based nanostructures, which are used to address problems in life science and materials. These materials are designed to (i) template/position nano-sized components such as nanoparticles, chromophores, electron donors, acceptors and catalytic centers to access light-harvesting devices for solar energy conversion into chemical energy, and (ii) precisely pattern memory, and other electronic components for data storage, and (iii) perform various biological tasks in living cells such as targeted delivery of molecular cargo (e.g drugs or proteins) to specific sites in cancer cells, and gene knockdown in a disease cell, and (iv) determine the concentrations of diverse biomolecules in real time at single cell level for eventual use as a medical diagnostic tool, and (v) analyze protein assemblies in biological pathways. A second active area in our group is the design and synthesis of advanced materials such as nanoparticles, organic small molecules and polymers for medical and bioanalytical research and applications. We are particularly interested in using the non-covalent interactions i.e. hydrogen bonding, and/or the dipole-dipole or ionic interactions to induce the self- assembly and recognition of the supramolecular nanostructures. My research projects are highly interdisciplinary and lie at the interface between synthetic chemistry, chemical biological and materials science. They provide students with extensive training in organic synthesis, DNA chemistry, as well as molecular recognition and live cell imaging. Keywords: DNA Chemistry, Molecular Self-Assembly, Live Cells Imaging, Synthetic Chemistry, Chemical Biology, Biomimetics

[4 Feb 2026] A Biomimetic Drug Delivery System by TNA Technology for Triple Negative Breast Cancer Therapy [13 Aug 2026] A Mitochondria-Targeting Organotin(IV) Bifunctional Scaffold for Colorectal Carcinoma [May 2026] Development of palladium-based multivalent lectin-directed artificial metalloenzymes [27 Mar 2026] Enrofloxacin Specific Aptamers And Uses Thereof [12 Jun 2026] Membrane Fusion-Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple-Negative Breast Cancer