Oscar Vargas-Rodriguez

We are a bacteriology lab studying the molecular bases that enable pathogenic bacteria to endure, acclimate, and prevail in the unwelcoming conditions of their host. Our research seeks to understand how bacterial pathogens regulate protein synthesis (translation) in response to interactions with their host, especially during colonization and infection. Our research focuses on the function of a family of translation factors known as aminoacyl-tRNA synthetases (aaRS). These enzymes are indispensable for life as they are responsible for the accurate and efficient translation of the genetic code during gene expression. We aim to understand the biological role of aaRSs during host-pathogen interactions as potential virulence factors and druggable targets using a combination of biochemical, biophysical, molecular, cellular, multi-omics, and computational approaches. In addition to our commitment to rigorous and innovative research, we strive to create a collegial and inclusive environment wherein our team trainees are supported and empowered to accomplish their career goals.

Journal Articles [2025] Mechanistic and evolutionary insights into a family of aminoacyl-tRNA deacylases that protects against canavanine toxicity. Maldonado, Juan S; Sepulveda, Stephanie; Karthikeyan, Sharva; Shirakawa, Karina T; Merced, Ivian; Radecki, Alexander A; Douglas, Jordan; Peti, Wolfgang; Page, Rebecca; Vargas-Rodriguez, Oscar Nucleic acids research 2025 Sep;53(17): [2025] An engineered glutamic acid tRNA for efficient suppression of pathogenic nonsense mutations. Specht, Caitlin; Tapia, Alejandro; Penrod, Sarah; Soriano, Gabriela A; Awawdeh, Aya; Alshawi, Sarah A; White, Cody A; Beaudoin, Jean-Denis; Doud, Emma H; Vargas-Rodriguez, Oscar; Huang, Yunjie; Tharp, Jeffery M Nucleic acids research 2025 Jun;53(12): [2024] AARS Online: A collaborative database on the structure, func