Matthew Sykes

Matt completed a Bachelor of Science honours degree in chemistry at Flinders University and subsequently completed a PhD at the same institution working in the field of molecular property prediction with Dr. Errol McCoy. After completing his PhD Matt worked as a Postdoctoral Research Associate at the University of Sheffield in the UK and at Astra Zeneca pharmaceuticals in Alderley Edge, Cheshire with Professor Barry Pickup and Dr Andrew Grant. This work centred around developing computational tools to expedite the drug development process, in particular looking at areas related to solvation of small molecules and proteins. Prior to moving to UniSA, Matt was working as a Research Fellow in the Department of Clinical Pharmacology at Flinders University with Professor John Miners, looking at computer-based methods for screening, identification and analysis of molecules of importance to human hepatic drug metabolism. Matt has won a number of awards for his teaching including: Division of Health Sciences Teaching Award (2009) Nominee, Student Nominated Excellent Educator Award (2010) University Supported Teacher Award (2011) UniSA Citation for Outstanding Contribution to Student Learning for "For sustained excellence in the teaching of chemistry to large first year student cohorts from a diverse range of programs and backgrounds" (2015) Cytochrome P450 structure-metabolism relationships, Molecular property prediction, Drug-membrane interactions

2024 - Janetzki, J., Sykes, M., Ward, M., & Pratt, N. (2024). Chronic Obstructive Pulmonary Disease adverse event signals associated with potential inhibitors of glutathione peroxidase 1: a sequence symmetry analysis. Drug Safety, 47(1), 59-70. 2023 - Fanta, B. S., Lenjisa, J., Teo, T., Kou, L., Mekonnen, L., Yang, Y., . . . Wang, S. (2023). Discovery of N,4-Di(1H-pyrazol-4-yl)pyrimidin-2-amine-Derived CDK2 Inhibitors as Potential Anticancer Agents: Design, Synthesis, and Evaluation. Molecules, 28(7), 2951. 2023 - Fanta, B. S., Mekonnen, L., Basnet, S. K. C., Teo, T., Lenjisa, J., Khair, N. Z., . . . Wang, S. (2023). 2-Anilino-4-(1-methyl-1H-pyrazol-4-yl)pyrimidine-derived CDK2 inhibitors as anticancer agents: Design, synthesis & evaluation. Bioorganic and Medicinal Chemistry, 80(117158),