Marianna Trakala

My laboratory investigates how chromosomal instability (CIN) and aneuploidy—hallmarks of cancer—impact tissue homeostasis, tumor development, and immune surveillance. We aim to understand the physiological responses to chromosome missegregation in vivo and uncover how aneuploidy shapes the tumor microenvironment and the immunopeptidome. Using mouse models, single-cell sequencing, and advanced imaging, we study how karyotypic alterations influence cell fate decisions, including immune recognition and clearance of aneuploid cells. We are particularly interested in dissecting how oncogenic transformation modulates these responses to promote cancer progression. Key research areas in the lab include cancer biology, tumor immunology, cell cycle regulation, and genome stability.