Luigi Perelli

Why do normal cells become tumor cells? My team's research program aims to advance our knowledge in this area of cancer biology to discover molecular hallmarks of malignant transformation. My group is focused on malignant transformation of renal and brain tumors; specifically on the environmental and cell-autonomous forces driving the acquisition of cancer cell features. The ultimate goal is to intercept cancer at the very early stages. My laboratory uses an array of molecular and functional genomics tools, including CRISPR/Cas technologies, mouse models, molecular barcoding, and induced pluripotent stem cells. Indeed, we have established multiple tools to track malignant transformation in real time. We are actively working on these technologies to potentiate their relevance with human disease, and to provide immediate translational opportunities for the development of biomarkers and identify vulnerabilities of pre-neoplastic cells. Students will be encouraged to develop bold hypotheses that aim to delineate the biological hallmarks of malignant transformation and tumor progression. Tutorial projects include investigating the role of metabolites in normal tissues driving the selection of pre-neoplastic cells, and the development of technologies to identify cell state specific lineages endowed with malignant potential. Additionally, my students will be expected to present their research at laboratory and scientific meetings, apply for fellowships, as well as write up their research for publication. I am committed to create a personalized training plan and to foster the growth of the new generation of scientists.