Linxin Li

My main research focuses on understanding the epidemiology, aetiology, and prognosis of strokes at younger ages. Our previous work has shown a doubling of stroke incidence under the age of 55 in the UK and in other high-income countries in the last decade. Yet the mechanistic driver remains unclear. I currently lead a fully phenotyped regional study (Thames Valley Young Stroke Study) and a national study (National Young Stroke Study) to improve our understanding of the underlying mechanisms and long-term impact of strokes at younger ages. My long-term goal is to understand the causes of stroke in younger adults and to develop improved risk stratification and prediction models, with the ultimate aim of advancing stroke prevention and management in this population. The other projects I'm working on include studying the association between blood pressure and cerebral small vessel disease, temporal trends of stroke incidence and outcome, and the risks and benefits of aspirin.

[2026] Time trends in stroke incidence and modifiable risk factor prevalence in England (2018-2024): A record linkage population-based study. Kamtchum-Tatuene J. et al, (2026), PLoS Med, 23 [2026] Persistence of Association of Blood Biomarkers With Risk of Recurrent Stroke on Long-Term Follow-Up: Population-Based Study. Li L. et al, (2026), Stroke [2026] Cerebral Artery Pulsatility, Premorbid Blood Pressure, and Small Vessel Disease on Brain Imaging: A Population-Based Study. Li L. et al, (2026), Neurology, 107 [2026] Temporal Patterns in Stroke Recurrence at Younger Ages. Nehme A. and Li L., (2026), JAMA Neurology, 83, 601 - 601 [2026] Temporal trends in case fatality, long-term survival, and vascular events after stroke in young and middle-aged individuals: A systematic review and meta-a