Lindsay Edward Wu

The Laboratory for Ageing Research is works on fundamental mechanisms and interventions that could maintain healthy ageing. These have immediate applications in other conditions, including slowing the decline in fertility with age, preventing the long-term adverse effects of chemotherapy treatment, and understanding why older people are so much more susceptible to coronavirus infection. The following projects and more are available for study at both the honours and PhD level... New treatments to maintain female fertility during biological ageing and following chemotherapy treatment; Role of the pentose phosphate pathway and the enzyme glucose-6-phosphate dehydrogenase in reproductive ageing; DNA transposons in genome instability and the regulation of lifespan; New treatments to reduce the side effects of chemotherapy and improve long-term health in cancer survivors; Studies of the metabolism of nicotinamide adenine dinucleotide (NAD+); Age-related changes in innate immunity and metabolism during coronavirus infection. Our lab uses molecular biology, animal physiology, metabolomics and bioinformatics to address our questions. We have maintained consistent NHMRC funding since 2015 and are always interested in passionate new lab members. Basic scientific research into the biology of ageing and age related disorders, with a focus on cell metabolism and the metabolic cofactor nicotinamide adenine dinucleotide (NAD+).