Liang ZHANG

Cancer-microenvironment interaction Mass spectrometry and proteomics Exosomes Wnt signaling Cell migration and metastasis Our research aims to elucidate the mechanisms by which cancer cells and the tumor microenvironment communicate with each other. The reciprocal interactions between cancer cells and the stromal tissues are recognized as a hallmark of cancer that plays a prime role in tumor initiation, growth, angiogenesis, invasion, metastasis, as well as drug resistance. The current research focus in the laboratory is exosomes, which are small extracellular vesicles that have gained increasing attention for their potent roles in mediating intercellular communication during cancer and other human diseases. We will employ multidisciplinary approaches that incorporate proteomics, genetics, molecular biology, biochemistry, and microscopy to dissect the signaling networks that are implicated in exosome-mediated cancer-stroma crosstalk. Over the next few years, my team will engage in the following areas of research: 1. To investigate the signaling networks that function in response to exosomes and Wnts to promote migration and metastasis of cancer cells. 2. To dissect the molecular machineries that facilitate the biogenesis and function of pro-metastasis exosomes. 3. To delineate the molecular mechanisms underlying exosomal association of Wnts, which are essential signaling proteins implicated in development and cancer. Overall these projects aim to elucidate of the molecular and signaling mechanisms that underlie the function of exosomes in cancer-stroma crosstalk. The outcomes will help exploit the full potential of exosomes to discover non-invasive biomarkers of cancer and other human diseases. In addition, we expect our research to open new windows for designing innovative exosome-based bioengineering and clinical applications.

[2026] Dissect Protein Interactions Using Mass Spectrometry. Liao, B. & Zhang, L., 12 Jan 2026, Targeting Protein–Protein Interactions for Drug Discovery. Zhang, J. (ed.). First ed. Wiley-VCH Verlag GmbH, p. 75-103 29 p. RGC 12 - Chapter in an edited book (Author) peer-review [2026] Dual-Organelle Secretome Conjugation and Organ-Uptake Tracking (DuO-SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins. Yang, F. (Co-first Author), Qian, R. (Co-first Author), Song, J., Meng, X., Kim, J. Y., Lai, K. O., Wang, L. & Zhang, L., 14 Aug 2026, (Online published) In: Advanced Science. e77190. RGC 21 - Publication in refereed journal peer-review [2026] Heterogeneous and specific localization of mRNAs at dendritic spine and its dependence on microtubule entry. Wang, X., Song, J., Lin, J.