Karin Borges

At the age of 15 I thought that I would like to develop new treatments for diseases where there is a need. After studying Biology in Germany and while working as a post-doctoral fellow with Professor Raymond Dingledine at Emory University, I became passionate about epilepsy. When starting my own laboratory at Texas Tech University, I began to investigate impairments in energy metabolism in epilepsy and potential new treatments to address energetic deficiencies. In 2011, I moved to UQ and have since enjoyed the many opportunities working with many talented students and professionals and within the globally highly respected Australin epilepsy community. Recent research: Among many other projects, my lab has characterized several metabolic alterations and impairments in energy metabolism in epilepsy (1, 2) and Motor Neuron Disease (1). In brain areas that can generate seizures, cytosolic and mitochondrial metabolism of glucose is impaired (1), which can lead to energy deficits and may trigger seizures. From a biochemical standpoint, auxiliary fuels such as ketone bodies and medium chain fatty acids derived from medium chain triglyceride (MCTs) are well suited to improve energy levels. We have also shown that different MCTs, including triheptanoin, when added to normal diets can prevent seizure generation in seizure models (reviewed here 1, 2) and prevent motor neuron death in an MND model (1). Our latest research aims to increase glucose transport into brain cells for glucose transporter 1 deficiency and epilepsy. Clinical sciences, Neurosciences, Pharmacology and pharmaceutical sciences

[2026] Neuronal Inhibition in Epilepsy: Native Human GABA-A Receptors and Pharmacological Chaperones Restoring Expression of Disease Associated Variants. Durisic, Nela and Borges, Karin (2026). Epilepsy Currents, 26 (3) 15357597251410849, 15357597251410849-247. doi: 10.1177/15357597251410849 [2025] Metabolic astrocytic support with decanoic acid enhances energy metabolism in Alzheimer’s disease models. Ameen, Aishat O., Rindshøj, Maja B., Dittlau, Katarina Stoklund, Borges, Karin, Freude, Kristine K. and Aldana, Blanca I. (2025). Cells, 14 (24) 2007, 1-18. doi: 10.3390/cells14242007 [2025] Could Glutamine Feed Epileptogenesis?. Borges, Karin (2025). Epilepsy Currents, 26 (1) 15357597251399047, 15357597251399047-61. doi: 10.1177/15357597251399047 [2025] Altered Glut4, IRAP , and brain insul