Joel Watts

Neurodegenerative disease, prions, protein conformation, Alzheimer’s, Parkinson’s Disease, Creutzfeldt-Jakob disease; Cell Biology, Molecular Medicine and Drug Discovery, Protein Structure and Dynamics; Protein Misfolding and Neurodegenerative Diseases; Investigating the Mechanisms of Prion Formation and Toxicity; The Expanding Universe of Prion Diseases; Are different “strains” of Aβ or α-synuclein aggregates responsible for the diverse clinical and pathological presentations of disease in humans?; What is the biochemical nature of the specific Aβ and α-synuclein assemblies that mediate spreading of protein aggregation during disease?; Can we take advantage of the prion-like behaviour of Aβ and α-synuclein aggregates in order to develop superior, more translational mouse models of human neurodegenerative diseases?