Jeffrey Gustafson

Research in the Gustafson group strives to apply innovative chemical strategies towards complex biological problems. Ongoing projects focus on three main areas (a) The development of chemical methodologies that enable the enantioselective synthesis of complex molecules; (b) The application of these methodologies to access new selective small molecule probes pertaining to aberrant protein phosphorylation; and (c) The design, synthesis and evaluation of small molecule vanadate complexes as phosphatase inhibitors.

"Controlling Ibrutinib's Conformations about Its Heterobiaryl Axis to Increase BTK Selectivity," Toenjes S.T., Heydari B.S., Albright S.T., Hazin R., Ortiz M.A., Piedrafita F.J., Gustafson J.L., ACS Medicinal Chemistry Letters 14, 305-311 (2023). (doi: 10.1021/acsmedchemlett.2c00523.) "Atropisomerism in the Pharmaceutically Relevant Realm," Basilaia M., Chen M.H., Secka J., Gustafson J.L., Accounts of Chemical Research 55, 2904-2919 (2022). (doi: 10.1021/acs.accounts.2c00500.) "Approaches toward Atropisomerically Stable and Conformationally Pure Diarylamines," Vaidya S.D., Heydari B.S., Toenjes S.T., Gustafson J.L., Journal of Organic Chemistry (2022). (doi: 10.1021/acs.joc.2c00451.) "Catalytic atroposelective dynamic kinetic resolutions and kinetic resolutions towards 3-arylquinolinesv