James Cuffe

Dr Cuffe is a systems physiologist focused on understanding the complex changes to maternal physiology that occur during pregnancy and the impact of pregnancy dysfunction of programmed cardiovascular, metabolic and renal disease in offspring. Dr Cuffe has a particular focus on understanding the role of the placenta and its hormones in mediating both maternal and offspring disease. He is most recognised for his research investigating how maternal stress, thyroid dysfunction, hypoxia or altered nutrition affect placental development and program disease in the mother after pregnancy as well as her offspring. Dr Cuffe has an exceptional track record and is excited to take new honours and PhD students into his research laboratory. Placental regulation of pregnancy disorders; Understanding the impact of thyroid disorders on pregnancy outcomes; Effects of maternal adversity on offspring physiology; Understanding the role of poorly understood nutrients in pregnancy health and fetal development; Understanding the impact of metformin on placental formation

[2026] Thyroid antibody positivity in pregnancy is associated with altered reproductive hormone concentrations and placental growth in Lewis rats [2025] Impact of diet and exercise in growth restricted female rats on nephron endowment in male fetuses [2025] Metformin and insulin exacerbate one‐carbon metabolism deficits in pregnant growth restricted rats and impacts the placenta, fetal liver and pancreas [2025] Dietary Fibre Modulates Gut Microbiota in Late Pregnancy Without Altering SCFA Levels, and Propionate Treatement Has No Effect on Placental Explant Function [2025] Prenatal alcohol exposure is associated with altered feto-placental blood flow and sex-specific placental changes [2025] Effects of periconceptional ethanol on mitochondrial content and oxidative stress in maternal liver