I-Ping Chen

In the Chen laboratory, we mainly focus on the investigation of pathogenic mechanisms of craniometaphyseal dysplasia (CMD) using multiple genetic and molecular biology approaches including a knock-in mouse model for CMD and induced pluripotent stem cells (iPSCs) from CMD patients. We have characterized the CMD mouse model replicating many features of human CMD and identified abnormal properties of osteoclasts and osteoblasts in CMD. Subsequently, I have generated integration-free induced pluripotent stem (iPS) cells from peripheral blood of CMD patients and control subjects. These hiPSCs will be differentiated into osteoclasts to study osteoclast defects in CMD. My long-term goal is to develop therapeutic strategies that can benefit patients with CMD and similar rare bone disorders. As an endodontist, I am also interested in dental research. In collaboration with Dr. Chon, a biomedical engineer, we aim to develop a quantitative and objective measurement for dental pain. We examine the use of electrodermal activity to assist pulpal diagnosis and assess dental pain. My laboratory has been funded by the American Association of Endodontists to establish a 3D culture modeling system that can be easily analyzed and improve or complement the current assays for testing new dental materials.

[2026] Complexity Analysis of Skin Nerve Activity for Quantitative Assessment of Acute Sympathetic Nervous System Activation. [2026] A tonic electrocutaneous stimulation paradigm for graded sensory C-fiber engagement in healthy subjects. [2025] Skeletal abnormalities caused by a Connexin43R239Q mutation in a mouse model for autosomal recessive craniometaphyseal dysplasia. [2024] ENPP1 enzyme replacement therapy improves ectopic calcification but does not rescue skeletal phenotype in a mouse model for craniometaphyseal dysplasia. [2023] Differentiating between stress- and EPT-induced electrodermal activity during dental examination. [2023] The use of electrodermal activity in pulpal diagnosis and dental pain assessment.