Guan YANG, 楊冠

Historically regarded as short-lived and functionally limited, neutrophils have been largely overlooked in the context of chronic autoimmune diseases. Our research program aims to investigate the pathogenic contribution of neutrophils in CNS autoimmunity and harness the therapeutic potential of targeting these cells. We are also expanding our research on neutrophils to include studies on multi-drug-resistant hypervirulent Klebsiella pneumoniae (hvKp) infections. In these studies, neutrophils are acknowledged as the first line of defense; however, they have proven ineffective in containing these superbugs. We aim to understand the mechanisms and develop immune-based therapies for these superbugs. We use a range of techniques to study this, including flow cytometry, histology, microscopy, single-cell and bulk RNA sequencing, and in vivo models using genetically-modified animals.

[2026] Combining polydopamine deposition and CsPbBr3@SiO2 QDs enables ultrasensitive and broadly specific monoclonal antibody-based in situ Salmonella imaging detection. Chen, B., Yang, X., Yang, G. & Chen, S., 6 Feb 2026, (Online published) In: Chinese Chemical Letters. RGC 21 - Publication in refereed journal peer-review [2026] Cytokine-driven PANoptosis of alveolar macrophages mediated by STAT1 underlies acute lung injury in hypervirulent Klebsiella pneumoniae infection. Xu, Q. (Co-first Author), Liu, X. (Co-first Author), Heng, H., Wang, H., Zhao, W., Luo, M., Yang, G., Peng, M., Chan, E.W.-C. & Chen, S., 13 May 2026, In: mBio. 17, 5, e03958-25. RGC 21 - Publication in refereed journal peer-review Open Access [2026] Gene expression signatures from single-cell transcriptomics predict Sj