Francesco Aprile

Our research focuses on the development of biomolecules as research tools to understand disease mechanisms, and for clinical applications. In particular, we use innovative high-throughput discovery methods to generate antibodies and peptides to study how the complex environment of the nervous system chemically modifies and modulates protein aggregates, called amyloids, which are a hallmark of many forms of dementia.

- A Potent Sybody Selectively Inhibits ɑ-Synuclein Amyloid Formation by binding the P1 Region. Gialama D, Vadukul DM, Thrush RJ, Radford S, Aprile FA. J Med Chem. (2024), 67, 9857–9868. DOI:10.1021/acs.jmedchem.3c02408. - α-Synuclein Aggregation is Triggered by Oligomeric Amyloid-β 42 via Heterogeneous Primary Nucleation. Vadukul DM, Papp M, Thrush RJ, Wang J, Jin Y, Arosio P, Aprile FA. J. Am. Chem. Soc. (2023) 145, 33, 18276–18285. DOI:10.1021/jacs.3c03212.