Ernesto Canalis
Professor of Orthopedic Surgery and Medicine, UConn Health · UConn Musculoskeletal Institute, UConn Health · University of Connecticut
Quick answer: Ernesto Canalis is Professor of Orthopedic Surgery and Medicine, UConn Health at University of Connecticut. Ernesto Canalis shows an active PhD hiring signal as of 2026-09-11.
⭐ Accepting Lab Rotation Students: Fall Block 2025, Spring 1 and 2 Block 2026. Projects available include --Role of Hes1 in osteoclast differentiation and function; --Role of Nfat in osteoblast differentiation and function; --Characterization of genetically engineered mice carrying Notch2 or Notch3 mutations; --Role of Notch in osteocyte function; --Role of vascular Notch in skeletal homeostasis; --
Research interests
Bone metabolism, osteoporosis, metabolic bone disorders, skeletal growth factors, glucocorticoid-induced osteoporosis, Notch signaling, NFAT in osteoblast and osteoclast differentiation, genetically engineered mouse models of Hajdu Cheney Syndrome and Lateral Meningocele Syndrome, translational research in bone disease.
Selected publications (since 2023)
[2026] Inactivation of Hes1 in Skeletal Undifferentiated Cells Increases Bone Volume. Endocrinology
[2025] NOTCH2 disrupts the synovial fibroblast identity and the inflammatory response of epiphyseal chondrocytes. The Journal of biological chemistry
[2025] A NOTCH2 pathogenic variant and HES1 regulate osteoclastogenesis in induced pluripotent stem cells. Bone
[2025] A NOTCH3 pathogenic variant influences osteogenesis and can be targeted by antisense oligonucleotides in induced pluripotent stem cells. PloS one
[2024] TNFα has differential effects on the transcriptome profile of selected populations in murine cartilage. Osteoarthritis and cartilage open
[2023] NOTCH2 Promotes Osteoclast Maturation and Metabolism and Modulates the Transcriptome Profile During Osteoclastogenesis. The Journal o
Frequently asked questions
Is Ernesto Canalis hiring PhD students at University of Connecticut?
Yes. As of 2026-09-11, Ernesto Canalis's faculty page shows a PhD hiring signal: Accepting Lab Rotation Students: Fall Block 2025, Spring 1 and 2 Block 2026. Projects available include --Role of Hes1 in osteoclast differentiation and function; --Role of Nfat in osteoblast differen.
What does Ernesto Canalis research?
Bone metabolism, osteoporosis, metabolic bone disorders, skeletal growth factors, glucocorticoid-induced osteoporosis, Notch signaling, NFAT in osteoblast and osteoclast differentiation, genetically engineered mouse models of Hajdu Cheney Syndrome and Lateral Meningocele Syndrome, translational rese
Data last updated: 2026-09-11 · Source: phd-match.com faculty database.
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