Dr John George Lock

Dr John Lock is Head of the Cancer Systems Microscopy lab within the School of Medical Sciences https://www.cancersystemsmicroscopylab.com Biography Dr Lock completed his doctorate within the Institute for Molecular Bioscience at the University of Queensland. He then began postdoctoral research at the Karolinska Institute in Stockholm with 5 years of back to back fellowships from the Wenner-Gren Foundation and the Swedish Cancer Foundation. He received accelerated promotion to Assistant Professor in recognition of his role in pioneering Systems Microscopy and leading a 9-person multidisciplinary team in its application to fundamental cancer research. Dr Lock returned to Australia with a senior position in the lab of Professor Katharina Gaus at UNSW, within the EMBL Node for Single Molecule Science. He helped conceive and fund formation of Australia’s first dedicated Systems Microscopy facility with $2.5M funding support from the Australian Research Council and the prestigious Ramaciotti Biomedical Research Award (co-CI, now academic lead of facility). This success enabled his initiation of the Cancer Systems Microscopy (CSM) lab in 2018. The CSM lab has since formed collaborations with an array of fundamental and translational cancer researchers, cancer clinicians, commercial microscopy and automation technology developers, as well as data science, machine / deep learning and visual analytics experts. This forms a truly multidisciplinary ecosystem of interactions. Reflecting these, Dr Lock is an invited member of the UNSW Steering Committee for the >$10M Expanded Perception & Interaction Centre (EPICentre) for data visualisation and AI research, the UNSW Data Science Hub (uDASH) and the UNSW AI & Data Science Network. More recently, Dr Lock has led Artificial Intelligence research to augment and integrate image data for both fundamental and precision medicine applications, res Dr Lock co-founded (with Professor Sarah Russell, PeterMacCallum Cancer Centre, Melbourne) the Systems Microscopy Australia Network to build and extend multidisciplinary capacity and collaborations across Australia and beyond, and has become a co-organiser of the Functional High Throughput Technologies Australia meeting, which focuses on screening-related technologies and their applications to drug discovery, precision medicine and functional genomics. Current Appointments & Positions Held Senior Lecturer, Head of Cancer Systems Microscopy lab, Department of Pharmacology, School of Biomedical Sciences Associate Director of Research for the School of Biomedical Sciences Deputy Chair of the School of Biomedical Sciences Research Strategy Committee Chair of HDR review panel and member of School of Biomedical Sciences HDR Committee Affiliate Researcher, Ingham Institute for Applied Medical Research UNSW Artificial Intelligence Institute member UNSW Data Science Hub member UNSW Artificial Intelligence Working Group member & Faculty of Medicine & Health Artificial Intelligence Working Group member Garvan Institute of Medical Research Imaging Platform Strategic Advisory Committee member Co-organiser, Functional High Throughput Technologies Australia meeting Membership in Societies Australian and New Zealand Society for Cell and Developmental Biology American Society for Cell Biology Australian Microscopy & Microanalysis Society Research keywords Cell Biology, Cancer, Liquid Biopsy, Circulating Tumour Cells, Imaging, Microscopy, Artificial Intelligence, Signalling, Statistics, Data Visualisation, Machine Learning, Deep Learning Cell Biology, Cancer, Liquid Biopsy, Circulating Tumour Cells, Imaging, Microscopy, Artificial Intelligence, Signalling, Statistics, Data Visualisation, Machine Learning, Deep Learning

An introduction to representation learning for single-cell data analysis Ihuan Gunawan, Fatemeh Vafaee, Erik Meijering, John G Lock Cell Reports Methods DOI: https://doi.org/10.1016/j.crmeth.2023.100547 Mapping Phenotypic Plasticity upon the Cancer Cell State Landscape Using Manifold Learning Daniel B. Burkhardt, Beatriz P. San Juan, John G. Lock*, Smita Krishnaswamy*, Christine Chaffer* Cancer Discovery DOI: https://doi.org/10.1158/2159-8290.cd-21-0282