Daria V Babushok

RESEARCH INTERESTS: The Babushok Lab conducts basic and translational research to understand the fundamental mechanisms by which bone marrow can fail, how bone marrow failure can lead to pre-malignant genetic changes and myelodysplastic syndrome and leukemia, and the relationship between our immune system and bone marrow failure and clonal hematopoiesis. We use state-of-the-art genome analysis, molecular biology and immunogenetic analyses, as well as in vitro and in vivo models to study the mechanisms of immune-mediated marrow failure and the factors that lead to the development of clonal hematopoiesis in bone marrow failure and aging. KEYWORDS: Clonal hematopoiesis, bone marrow failure, aplastic anemia, PNH, telomere biology disorders, germline predisposition, myelodysplastic syndrome (MDS) and leukemia

Sande CM, Chen S, Mitchell DV, Lin P, Abraham DM, Cheng J, Gebhard T, Deolikar RJ, Freeman C, Zhou M, Kumar S, Bowman M, Bowman RL, Zheng S, Munkhbileg B, Chen Q, Stanley NL, Guo K, Lapite A, Hausler R, Taylor DM, Corines J, Morrissette JJD, Lieberman DB, Yang G, Shestova O, Gill S, Zheng J, Simmer KS, Banaszak LG, Shoger K, Reinig EF, Peterson M, Nicholas P, Walne AJ, Dokal I, Rosenheck JP, Oetjen KA, Link DC, Gelman AE, Reilly CR, Dutta R, Lindsley RC, Brundige K, Agarwal S, Bertuch AA, Churpek JE, Tague LK, Johnson FB, Olson TS, Babushok DV. : ATM-dependent DNA damage response constrains cell growth and drives clonal hematopoiesis in telomere biology disorders. J Clin Invest 135(8): e181659. Apr 2025. Höchsmann B, Gerber GF, Leopold W, Patel BJ, Gavriilaki E, Hefter A, Kalhammer U, Opit