Daniel Moriarity

Precision psychopathology Psychoneuroimmunology Methodological reform Research Synopsis Dr. Daniel P. Moriarity directs the The Precision Psychopathology + Dynamic Immunopsychiatry (PPDI) Lab at UPenn. This lab conducts research focused on the dynamic interplay between stress, immunology, and affective psychopathology (depression, anxiety and hypo/mania). Using these research areas as a canvas, the broader mission of this lab is to identify facets of "precision" that are fundamental to making precision medicine the new status quo for mental health research and clinical practice. For example, (1) refining symptom-level clinical phenotypes associated with immunology, (2) advancing standards for biological data collection and modeling via physiometric research, and (3) integrating plausible biological mechanisms into robustly supported psychosocial frameworks of psychopathology risk, resilience, and treatment. This lab uses a breadth of methods (ecologically valid stress paradigms, acute stress tasks, psychological and pharmacological clinical trials) in pursuit of this mission. By conducting work that spans the basic-to-clinical research continuum, we aspire to equally contribute to both raising the methodological bar in biological psychology and informing the development and implementation of treatments. A complete list of publications can be found at https://scholar.google.com/citations?user=zTCuAVcAAAAJ&hl=en Professor Daniel Moriarity will be considering new graduate students for admission for Fall 2026.

Moriarity, D. P., & Slavich, G. M. (2023). The future is dynamic: A call for intensive longitudinal data in immunopsychiatry. Brain, behavior, and immunity, 112, 118-124. Moriarity, D. P., Mengelkoch, S., & Slavich, G. M. (2023). Incorporating causal inference perspectives into psychoneuroimmunology: A simulation study highlighting concerns about controlling for adiposity in immunopsychiatry. Brain, Behavior, and Immunity, 113, 259-266. Moriarity, D. P., Slavich, G. M., Alloy, L. B., & Olino, T. M. (2023). Hierarchical inflammatory phenotypes of depression: a novel approach across five independent samples and 27,730 adults. Biological psychiatry, 93(3), 253-259. Moriarity, D. P., Grehl, M. M., Walsh, R. F., Roos, L. G., Slavich, G. M., & Alloy, L. B. (2023). A systematic review of associat