Clarke, Steven G.
Distinguished Professor · University of California, Los Angeles · University of California, Los Angeles
Quick answer: Clarke, Steven G. is Distinguished Professor at University of California, Los Angeles. Clarke, Steven G. shows an active PhD hiring signal as of 2026-09-11.
⭐ Professor Clarke accepts graduate students through the Biochemistry, Molecular and Structural Biology (BMSB) Graduate Program and the UCLA ACCESS Ph.D. Program.
Research interests
Dr. Clarke has established the paradigm that biological aging is no less than war waged between chemistry and biology. Chemistry represents the spontaneous reactions that degrade biomolecules and biology represents the response of the organism to limit the chemical damage. His laboratory discovered and has characterized a novel pathway that has demonstrated that macromolecular repair is not just for DNA, but for proteins as well! These studies have not only given us a new window to view protein “life” but also suggest that the biological aging process may be closely linked to how well one can keep polypeptides free of spontaneous damage. He has gone on to show that the enzymatic recognition of damage is not limited to DNA and proteins but is a more general response of cells to molecular damage, particularly of crucial metabolites such as <i>cis</i> -aconitate and <i>S</i> -adenosylmethionine. His laboratory has also been in the forefront of identifying new types of methyltransferases that are involved in cellular signaling reactions. His laboratory has discovered enzymes that modify signaling proteins by methylation reactions at C-terminal isoprenylated cysteine residues and leucine residues, as well the first member of the family of protein arginine methyltransferases involved in multiple cellular processes including DNA repair, gene expression, protein translocation, and signaling.
Selected publications (since 2023)
- Lowe, T. L.; Valencia, D. A.; Velasquez, V. E.; Quinlan, M. E.; Clarke, S. G. (2024) <a class="waffle-rich-text-link" href="https://dx.doi.org/10.1016/j.jbc.2024.107857">Methylation and phosphorylation of formin homology domain proteins (Fhod1 and Fhod3) by protein arginine methyltransferase 7 (PRMT7) and Rho kinase (ROCK1)</a> – J. Biol. Chem. 300, 107857. DOI: <a href="https://doi.org/10.1016/j.jbc.2024.107857.">10.1016/j.jbc.2024.107857</a>.
- Clarke, S. G. and Eisenberg, D. S. (2024) “<a href="https://www.biochemistry.ucla.edu/Faculty/SClarke/pdf/312_Holtz_et_al_ADMA_SDMA_Met_addicted_cancer_cells_2023.pdf">Paul Delos Boyer: A Biographical Memoir</a>” Biographical Memoirs, National Academy of Sciences. Online publication available at: <a href="https://www.nasonline.org/pu
Frequently asked questions
Is Clarke, Steven G. hiring PhD students at University of California, Los Angeles?
Yes. As of 2026-09-11, Clarke, Steven G.'s faculty page shows a PhD hiring signal: Professor Clarke accepts graduate students through the Biochemistry, Molecular and Structural Biology (BMSB) Graduate Program and the UCLA ACCESS Ph.D. Program..
What does Clarke, Steven G. research?
Dr. Clarke has established the paradigm that biological aging is no less than war waged between chemistry and biology. Chemistry represents the spontaneous reactions that degrade biomolecules and biology represents the response of the organism to limit the chemical damage. His laboratory discovered
Data last updated: 2026-09-11 · Source: phd-match.com faculty database.
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