Brandon Ashfeld

Our research program is focused on the development of new methods to enable unconventional bond formations in the synthesis of complex natural products and designed materials. Our main objective is to use new chemical constructs to design and synthesize improved chemotherapies for brain and CNS cancers, and materials that will ultimately lead to the reduction of atmospheric concentrations of anthropogenic CO2.

Gu, K.; Hall, M. T.; Tucker, Z. D.; Durling, G. M. and Ashfeld, B. L. "Catalyst-Controlled Directing Group Translocation in the Site Selective C-H Functionalization of 3-Carboxamide Indoles and Metallocarbenes" 2025 Nature Communications, 16 (1), 97. DOI: 10.1038/s41467-024-55246-2. Deng, S. K.; Liu, T. A.; Ilnytska, O.; Allada, T.; Fomina, A.; Lin, N.; Petukhova, V. Z.; Pathmasiri, K. C.; Chinthapally, K.; Blagg, B.; Ashfeld, B. L.; Cologna, S. M. and Storch, J. "Molecular Determinants of Phospholipid Treatment to Reduce Intracellular Cholesterol Accumulation in NPC1 Deficiency" 2024 Journal of Biological Chemistry, 300 (11), 107889. DOI: 10.1016/j.jbc.2024.107889. Azaria, R. D.; Correia, A. B.; Schache, K. J.; Zapata, M.; Pathmasiri, K. C.; Mohanty, V.; Nannapaneni, D. T.; Ashfeld, B. L.