Alireza Ghanbarpour
Assistant Professor of Biochemistry and Molecular Biophysics, Assistant Professor of Molecular Microbiology, Assistant Professor of Cell Biology & Physiology · WashU Medicine · Washington University in St. Louis
⭐ Available to Mentor: PhD Students
Research interests
Our research focuses on unraveling the molecular mechanisms underlying substrate specificity and degradation by AAA proteolytic machines and their associated adaptor proteins, utilizing structural biology, biochemistry, and cellular assays in both bacteria and human mitochondria.
Selected publications (since 2023)
[2026] An open axial channel of the AAA ClpXP protease enhances degradation of specific classes of protein substrates
[2026] Bacterial immune activation via supramolecular assembly with phage triggers
[2025] An asymmetric nautilus-like HflK/C assembly controls FtsH proteolysis of membrane proteins
[2025] Exploiting a rational β-strand insertion strategy and disulfide locking to mechanically manipulate domain-swapped protein structures
[2025] Structural insights into the Pseudomonas aeruginosa ClpP1•ClpP2 heterocomplex and its interactions with the AAA+ ClpX unfoldase
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