Alecia-Jane Twigger

Cambridge Lactation Lab: Modelling human lactation to support long-term health. Understanding how human lactation works, identifying innovative strategies to improve breastfeeding, particularly in women with low supply, to enhance the long-term health outcomes of women and children. Research objectives: What are the biosynthesis pathways involved in the synthesis and secretion of human milk? What factors are necessary to render human milk organoids to produce milk? Is there lactocyte cell specification to make different components of milk? What is the molecular basis of low milk production? What key factors influence a mammary cell to develop normally (i.e. produce milk) compared to abnormally (i.e. breast cancer).

[2024] Reed, A. D. Pensa, S., Steif, A., Stenning, J., Kunz, D. J., Porter, L. J. Kui Hua, He, P., Twigger, A.J., Siu, A., J.Q., Kania, K., Barrow-McGee, R., Goulding, I., Gomm, J.J., Speirs, V., Jones, J. L., Marioni, J.C.*, Khaled, W.T.* "A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast" Nature genetics 56 (4), 652-662, 2024