Adam Melvin

Development of new tools and technologies to quantify and characterize complex biological systems; interdisciplinary approach combining chemical and biomedical engineering with chemical biology, biochemistry, biophysics, cell biology, and cancer biology; biosensor projects including long-lived, cell-permeable, peptide-based biosensors for high-throughput screening of DUB and proteasome activity in intact single cells using droplet microfluidics; microfluidic devices to study metastatic breast cancer including gradient generators for co-culture effects, on-chip generation of 3D spheroids, fluid shear stress effects on breast cancer cell phenotype, and 3D-printed molds for cancer cell migration; exploring long-lived, cell-permeable peptides as novel proteolysis targeting chimeras (PROTACs).